Deudomperidone (CIN-102) is a Dopamine 2/3 antagonist with prokinetic and antiemetic effects.

Phase 2


CinDome’s deudomperidone (CIN-102) is a new chemIcal entity, based upon deuteration and novel formulation of domperidone, a frequently prescribed first line therapy for nausea, vomiting, and gastroparesis outside of the United States. In part due to safety concerns around QT prolongation, domperidone is not approved in the U.S. Deudomperidone has been engineered to alter the PK profile for sustained efficacy while significantly reducing cardiac liability. Currently, 20-50% of patients with gastroparesis use off-label treatments or go untreated, leaving a major unmet medical need and significant therapeutic development opportunity.


CinDome has studied deudomperidone in multiple clinical trials to date. Deudomperidone was well tolerated in these studies, and there were no sponsor-assessed drug related adverse events (AEs) or clinically meaningful laboratory abnormalities.  Deudomperidone was deemed to have no meaningful impact on QT at exposures well above a therapeutic dose in a TQT study and demonstrated target engagement with trends of improvement in gastric emptying time in a previous Phase 2 clinical trial.



CinDome is currently enrolling the envision3D Deuterated Domperidone in Diabetic GP – clinical trial. envision3D  is a randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of deudomperidone (CIN-102) in adult subjects with diabetic gastroparesis after 12 weeks of treatment. To learn more about the clinical trial and participation information, please visit or NCT Number NCT05832151.


1. Rey E, Choung RS, Schleck CD, Zinsmeister AR, Talley NJ, Locke GR 3rd. Prevalence of hidden gastroparesis in the community: the gastroparesis “iceberg”. J Neurogastroenterol Motil. 2012 Jan;18(1):34-42
2. Jung HK, Choung RS, Locke GR 3rd, et al. The incidence, prevalence, and outcomes of patients with gastroparesis in Olmsted County, Minnesota, from 1996 to 2006. Gastroenterology. 2009;136(4):1225-1233


12-16 million patients in the US have symptoms of gastroparesis

>$4B annual prescription market in the US

Currently no chronic treatments available