CinDome Pharma Announces $40 Million Series B Extension

  • $40 million extension from existing investors Perceptive Advisors and CinRx Pharma brings the total Series B funding to $59 million


  • Extension to support continued development of deudomperidone (CIN-102) for the treatment of chronic gastroparesis, including preparation for registrational trials


  • Deudomperidone has the potential to become the first approved therapy in the U.S. for the long-term treatment of gastroparesis


CINCINNATI – May 16, 2024 – CinDome Pharma, a CinRx portfolio company dedicated to advancing a safe, chronic therapy for gastroparesis, today announced a $40 million Series B financing extension. The additional funds from existing investors, including Perceptive Advisors and CinRx Pharma, bring the Series B raise total to $59 million. The capital will support the ongoing enrollment and evaluation of deudomperidone in the Phase 2 envision3D study in adults with diabetic gastroparesis and position the company for registrational trials.


Gastroparesis is an area of high unmet medical need, impacting an estimated 12-16 million people in the U.S. alone, with an incidence rate growing on pace with diabetes and no U.S. Food and Drug Administration (FDA) approved long-term treatment option. CinDome’s deudomperidone is a new chemical entity being evaluated to address the unmet need in gastroparesis as a novel formulation of domperidone, a frequently prescribed first-line therapy for nausea, vomiting and gastroparesis outside of the U.S.


“This increased investment in CinDome extends our important, ongoing development activities and enables readiness for deudomperidone to enter late-stage trials,” said Dr. Jon Isaacsohn, Founder and Chief Executive Officer at CinRx Pharma. “We are grateful for the continued support and partnership from Perceptive Advisors to advance this high-impact therapeutic and bring a new hope to people impacted by gastroparesis.”


About Deudomperidone (CIN-102)

Deudomperidone is a new chemical entity based upon deuteration and novel formulation of domperidone, a frequently prescribed first-line therapy for nausea, vomiting and gastroparesis outside of the U.S. In part due to safety concerns around QT prolongation, domperidone is not approved in the U.S. Deudomperidone has been engineered to alter the PK profile for sustained efficacy while significantly reducing cardiac liability. Multiple clinical trials of deudomperidone demonstrated it was well tolerated, including no sponsor-assessed drug related adverse events (AEs) or clinically meaningful laboratory abnormalities. Deudomperidone was deemed to have no meaningful impact on QT at exposures well above a therapeutic dose in a thorough QT study and demonstrated target engagement and improvement in gastric emptying time in a previous Phase 2a trial.


About CinDome Pharma

CinDome, a CinRx portfolio company, is dedicated to filling the significant need for a safe, effective and tolerable treatment for the millions of people living with the devastating impact of chronic gastroparesis. ​With nearly 16 million adult patients in the U.S. experiencing symptoms of gastroparesis, a safe and effective treatment that can be taken on a chronic basis remains a significant unmet need. CinDome’s deudomperidone (CIN-102) is an engineered formulation of well-known D2/D3 antagonist, domperidone, which is the first line treatment for gastroparesis worldwide but not approved in the U.S. ​


About CinRx Pharma

CinRx Pharma is a biotech company advancing a diverse portfolio of high-impact medicines through clinical development with a unique hub-and-spoke business model. CinRx’s approach combines financing with the efficient progression of therapeutic candidates within its portfolio, each managed by CinRx’s central infrastructure and operating team. Current CinCos address areas of high unmet medical need including metabolic, gastrointestinal and oncology. Differentiated by an asset selection process agnostic to therapeutic area, a strategic CRO partnership, and insights from thousands of development programs, CinRx identifies, funds and accelerates promising drugs with the potential to have the highest impact on patients’ quality of life. CinRx Pharma is headquartered in Cincinnati, Ohio.


For more information, please visit or follow the company on X and LinkedIn.


Media Contact:

Cassidy McClain

Vice President, Communications

[email protected]


CinRx Pharma Contact:

Jason Westerheide

Executive Director, Business Development

[email protected]