CIN-108 is a small molecule inhibiting defective in cullin neddylation 1 (DCN1) from binding in the pocket where is it necessary to promote neddylation and interfere with the progression of multiple cancers.
CIN-108
OVERVIEW:
CinSano’s CIN-108, a small molecule compound that inhibits a novel, well-studied oncogene target, DCN1, which is amplified in multiple cancer types and correlates with more severe prognosis. Licensed in 2021 by CinRx, the goal for CIN-108 is to disrupt the neddylation pathway by preventing binding of DCN1 to the pocket necessary for it to promote neddylation. The CIN-108 compound series is currently being optimized.
Sources:
American Cancer Society
Solid Tumor
Metrics:
Represent approximatively 90% of adult human cancers
REASONS
TO BELIEVE
- Cancer is the leading cause of death in US, with solid tumors represnting approximately 90% of adult human cancers.
- DCN1 is well-studied oncogene that increases efficiency of neddylation and has multiple function inlcuding:
- Tumor progression
- Chemosensitivity
- Angiogenesis
- Metastasis
- Neddylation promotes degradation of vrious substrates, including tumor suppressors
- Neddylation pathway is over-activated in multiple tumors types(Lung, liver, colon, glioblastoma, esophageal squmous cell)