CinRx Portfolio Company CinDome Pharma Presents Encouraging Data on Deudomperidone (CIN-102) at 2023 Digestive Disease Week® Conference

Deudomperidone is an orally active dopamine D2/D3 antagonist in development as the first therapy for the long-term treatment of gastroparesis


Results demonstrate deudomperidone has no clinically meaningful impact on QT intervals


CINCINNATI – May 8, 2023 – CinDome Pharma, a CinRx portfolio company, presented a poster at the 2023 Digestive Disease Week (DDW) Conference titled “Effect of Therapeutic and Supratherapeutic Doses of Deudomperidone (CIN-102) on Cardiac Repolarization in a Thorough QT (TQT) Study in Healthy Subjects.” The poster highlighted data evaluating deudomperidone, a modified formulation of domperidone, for the long-term treatment of gastroparesis.


The study presented at DDW assessed the effect of deudomperidone on electrocardiogram (ECG) parameters, including concentration-QTc (C-QTc) analysis. In this randomized placebo and active-controlled trial of deudomperidone in healthy individuals aged 18-55 years of age, the treatment did not have a clinically meaningful effect on ECG parameters at the therapeutic and supratherapeutic levels. The data demonstrated the potential of deudomperidone to decrease the risk of QT prolongation associated with the traditional formulation of domperidone.


“We’re extremely pleased with the results of this thorough QT study and have already advanced the clinical development of deudomperidone by initiating a phase 2 clinical trial to support patients with diabetic gastroparesis, a population with a large unmet medical need” said Jon Isaacsohn, MD, FACC, Founder and Chief Executive Office at CinRx Pharma.


Deudomperidone is being developed by CinDome as the first line therapy for chronic gastroparesis, which impacts an estimated 16 million people in the US. This novel formulation of domperidone is designed to blunt peak concentration (Cmax) and extend half-life as compared to traditional domperidone. Deudomperidone is intended to provide similar or better therapeutic effects than domperidone with less QT liability.  Currently, the only US-approved treatment for gastroparesis is metoclopramide, which is only prescribed for short-term treatment and carries a black box warning.


Details of the poster presentation are as follows:


Session Title: AGA Gastroparesis and Small Intestinal Dysmotility 
Session Sponsor: AGA 
Session Date and Time:
May 7, 2023, from 12:30 PM to 1:30 PM 
Poster Number: Su1638 


Digestive Disease Week® (DDW) is the largest international gathering of physicians, researchers and academics in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Jointly sponsored by the American Association for the Study of Liver Diseases (AASLD), the American Gastroenterological Association (AGA), the American Society for Gastrointestinal Endoscopy (ASGE) and the Society for Surgery of the Alimentary Tract (SSAT), DDW is an in-person and online meeting from May 6-9, 2023. The meeting showcases more than 3,100 abstracts and hundreds of lectures on the latest advances in GI research, medicine and technology. More information can be found at



About CinRx Pharma

CinRx is a mosaic of biotechnology companies supported by a dedicated funding mechanism designed to improve drug development success and accelerate transformational new medicines to patients. By integrating our deep scientific, clinical, and operational expertise with a thoughtful portfolio model, we establish the optimal development trajectory – a drug development superhighway. The company’s experienced team ensures high-potential medicines are financially and operationally championed with the most efficient route from the lab to the patient. For more information, please visit or follow the company on Twitter and LinkedIn.


About CinDome Pharma

CinDome, a CinRx portfolio company, is dedicated to filling the significant need for a safe, effective and tolerable treatment for the millions of people living with the devastating impact of chronic gastroparesis. ​With nearly 16 million adult patients in the US experiencing symptoms of gastroparesis, a safe and effective treatment that can be taken on a chronic basis remains a significant unmet need. CinDome’s CIN-102 is an engineered formulation of domperidone, the first line treatment for gastroparesis worldwide, which is not approved in the US. ​


CinRx Pharma Contact:

Jason Westerheide

Executive Director, Business Development

[email protected]


Media Contact:

Cassidy McClain

Account Director, Communications

[email protected]